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Specialty

Cellular and Molecular Physiopathology

Declaration of interest areas

Lines of work and know-how:

• Vascular channelopathies: control of vascular tone and hypertension
• Epithelial channelopathies: chronic respiratory diseases
• Neuronal channelopathies: migraine
• Etiopathogenics and physiopathology of Alzheimer disease

Latest publications

• Ill-Raga G, Tajes M, Busquets-García A, Ramos-Fernández E, Vargas LM, Bosch-Morató M, Guivernau B, Valls-Comamala V, Eraso-Pichot A, Guix FX, Fandos C, Rosen MD, Rabinowitz MH, Maldonado R, Alvarez AR, Ozaita A, Muñoz FJ Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis. Antioxid. Redox Signal. 2015; 22: 1295-307

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• Garcia-Elias A, Berna-Erro A, Rubio-Moscardo F, Pardo-Pastor C, Mrkonjic S, Sepúlveda RV, Vicente R, González-Nilo F, Valverde MA Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels. Structure 2015; 23: 1404-13

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• Cuadrado-Godia E, Regueiro A, Núñez J, Díaz-Ricard M, Novella S, Oliveras A, Valverde MA, Marrugat J, Ois A, Giralt-Steinhauer E, Sanchis J, Escolar G, Hermenegildo C, Heras M, Roquer J Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy. PLoS ONE 2015; 10: e0132415

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• Ill-Raga G, Palomer E, Ramos-Fernández E, Guix FX, Bosch-Morató M, Guivernau B, Tajes M, Valls-Comamala V, Jiménez-Conde J, Ois A, Pérez-Asensio F, Reyes-Navarro M, Caballo C, Gil-Gómez G, Lopez-Vilchez I, Galán AM, Alameda F, Escolar G, Opazo C, Planas A, Planas AM, Roquer J, Valverde MA, Muñoz FJ Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death. Biochim. Biophys. Acta 2015; 1852: 421-8

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• Regueiro A, Cuadrado-Godia E, Bueno-Betí C, Diaz-Ricart M, Oliveras A, Novella S, Gené GG, Jung C, Subirana I, Ortiz-Pérez JT, Roqué M, Freixa X, Núñez J, Escolar G, Marrugat J, Hermenegildo C, Valverde MA, Roquer J, Sanchis J, Heras M Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: time-course after acute myocardial infarction and stroke. J. Mol. Cell. Cardiol. 2015; 80: 146-55

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• Fernández-Mariño AI, Cidad P, Zafra D, Nocito L, Domínguez J, Oliván-Viguera A, Köhler R, López-López JR, Pérez-García MT, Valverde MA, Guinovart JJ, Fernández-Fernández JM Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle. PLoS ONE 2015; 10: e0118148

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• Kiefer K, Carreras-Sureda A, García-López R, Rubio-Moscardo F, Casas J, Fabriàs G, Vicente R Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells. J. Biol. Chem. 2015; 290: 2822-30

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• Vicario-Orri E, Opazo CM, Muñoz FJ The pathophysiology of axonal transport in Alzheimer's disease. J. Alzheimers Dis. 2015; 43: 1097-113

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• Mrkonjic S, Garcia-Elias A, Pardo-Pastor C, Bazellières E, Trepat X, Vriens J, Ghosh D, Voets T, Vicente R, Valverde MA TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells. Pflugers Arch. 2015; 467: 2107-19

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• Garcia-Elias A, Mrkonjic S, Jung C, Pardo-Pastor C, Vicente R, Valverde MA The TRPV4 channel. Handb Exp Pharmacol 2014; 222: 293-319

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