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Novensá L, Novella S, Medina P, Segarra G, Castillo N, Heras M, Hermenegildo C, Dantas AP

Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice.

PLoS ONE. 2011;6(9):e25335, PMID: 21966501

Aging is among the major causes for the lack of cardiovascular protection by estrogen (E2) during postmenopause. Our study aims to determine the mechanisms whereby aging changes E2 effects on nitric oxide (NO) production in a mouse model of accelerated senescence (SAM).

BIOLOGY

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Ministerio de Economía y Competitividad Fondo Europeo de Desarrollo Regional IMIM - Parc de Salut Mar