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Jung C, Gené GG, Tomás M, Plata C, Selent J, Pastor M, Fandos C, Sentí M, Lucas G, Elosua R, Valverde MA

A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction.

Cardiovasc. Res.. 2011 Aug;91(3):465-71, PMID: 21427121

The TRPC4 non-selective cation channel is widely expressed in the endothelium, where it generates Ca(2+) signals that participate in the endothelium-mediated vasodilatory response. This study sought to identify single-nucleotide polymorphisms (SNPs) in the TRPC4 gene that are associated with myocardial infarction (MI).


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Ministerio de Economía y Competitividad Fondo Europeo de Desarrollo Regional IMIM - Parc de Salut Mar