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Garrido-Martín EM, Blanco FJ, Roqué M, Novensá L, Tarocchi M, Lang UE, Suzuki T, Friedman SL, Botella LM, Bernabéu C
Vascular injury triggers Krüppel-like factor 6 mobilization and cooperation with specificity protein 1 to promote endothelial activation through upregulation of the activin receptor-like kinase 1 gene.
Circ. Res.. 2013 Jan;112(1):113-27, PMID: 23048070
Activin receptor-like kinase-1 (ALK1) is an endothelial transforming growth factor β receptor involved in angiogenesis. ALK1 expression is high in the embryo vasculature, becoming less detectable in the quiescent endothelium of adult stages. However, ALK1 expression becomes rapidly increased after angiogenic stimuli such as vascular injury.
CARDIAC & CARDIOVASCULAR SYSTEMS
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