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Method and kit for the detection of hypertension risk

Application Number: 200400883

A prognostic or diagnostic method for use in human essential hypertension that detects the presence or absence of a polymorphism in the KCNMB1 gene in a sample taken from a human patient, causing an amino acid substitution in the polymorphism that replaces E (glutamic acid) with K (lysine) in position 65 of the corresponding coded polypeptide. In particular, the polymorphism is a replacement of the unique G nucleotide in position 352 of the KCNMB1 gene sequence with an A nucleotide. Methods, composites, and kits are presented for the diagnosis and prognosis of essential hypertension in humans. Composites are also provided that offer prophylactic or curative treatment of essential hypertension.

Related publications

  • Ferreira-González I, Permanyer-Miralda G, Heras M, Cuñat J, Civeira E, Arós F, Rodríguez JJ, Sánchez PL, Marsal JR, Ribera A, Marrugat J, Bueno H. Patterns of use and effectiveness of early invasive strategy in non-ST-segment elevation acute coronary syndromes: an assessment by propensity score. Am. Heart J. 2008 Nov; 156(5): 946-53, 953.e2

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Ministerio de Economía y Competitividad Fondo Europeo de Desarrollo Regional IMIM - Parc de Salut Mar